After 25 years studying the links between Type 2 diabetes and obesity, Jackie Stephens and a team of LSU researchers have identified a new player, the protein oncostatin, that could help us better understand how inflammation in fat tissue affects insulin resistance.
Stephens and her colleagues from LSU, Pennington Biomedical Research Center and the LSU School of Veterinary Medicine are investigating the inflammatory aspect of diabetes by observing the direct effects of oncostatin, or OSM, a protein produced in fat, also known as adipose tissue.
To better understand the role of OSM in adipose tissue inflammation, Stephens and her research team used mouse models to examine the effects of the protein in obese mice. In these sophisticated animal models, they found that OSM acts as a mediator and promoter in many processes that affect insulin resistance.
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