Nature, Published online: 29 March 2024; doi:10.1038/d41586-024-00902-2The evidence is equivocal on whether screen time is to blame for rising levels of teen depression and anxiety — and rising hysteria could distract us from tackling the real causes.
Nature, Published online: 28 March 2024; doi:10.1038/d41586-024-00957-1A genetic eye condition pushed biochemist Kamini Govender to develop coping strategies that serve her well in the lab and help her to avoid burnout.
Nature, Published online: 28 March 2024; doi:10.1038/d41586-024-00414-zConvincing evidence of 1:1 tidal locking has been absent until a new analysis of the exoplanet LHS 3855b.
Nature, Published online: 28 March 2024; doi:10.1038/d41586-024-00960-6Organizations who received funds from FTX face pressure to return the money at significant operational cost.
Nature Genetics, Published online: 28 March 2024; doi:10.1038/s41588-024-01688-9Single-cell RNA sequencing analysis of over 800,000 human adult breast cells from 55 female donors identifies 41 cell subtypes and highlights age- and parity-dependent effects. Samples from healthy women with germline mutations in BRCA1 or BRCA2 showed signs of T cell exhaustion.
Nature Genetics, Published online: 28 March 2024; doi:10.1038/s41588-024-01702-0Single-cell transcriptomics and expression quantitative trait locus mapping in 114 lung tissue samples, including 66 with interstitial lung disease, highlight the cell-type-specific functions of risk variants contributing to disease pathobiology.
Nature Genetics, Published online: 28 March 2024; doi:10.1038/s41588-024-01684-zIncorporating protein-altering copy number variants ascertained from UK Biobank whole-exome sequencing data into analyses of rare predicted loss-of-function variants identifies complex trait associations not detectable using standard analysis methods.
Nature Genetics, Published online: 25 March 2024; doi:10.1038/s41588-024-01690-1In mice, zygotic genome activation occurs at onset of the two-cell stage in embryonic development and coincides with the exit from totipotency. Our work shows that the transcription factor DUXBL participates in silencing part of the stage-specific two-cell-associated transcriptional program and is required for development to proceed.